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Identification of Noncanonical Transcripts Produced by Systematic Nucleotide Exchanges in HIV-Associated Centroblastic Lymphoma.
DNA and Cell Biology ( IF 2.6 ) Pub Date : 2020-07-30 , DOI: 10.1089/dna.2019.5066
Ganesh Warthi 1, 2 , Pierre-Edouard Fournier 1, 2 , Hervé Seligmann 3
Affiliation  

Noncanonical transcriptions include transcriptions that systematically exchange nucleotides, also called bijective transformations or swinger transformations. Swinger transformation A↔T+C↔G recovers identities of 8 among 9 unknown RNAs differentially expressed in centroblastic lymphoma, a human immunodeficiency virus (HIV)-associated non-Hodgkin's lymphoma. The identified RNAs align with human genes with known anti-HIV1 or oncogenic activities. Function disruption through swinger-transformed transcription potentially enables avoiding antiviral responses and contributes to cancer induction.

中文翻译:

鉴定与艾滋病毒相关的成胶质细胞淋巴瘤中的系统性核苷酸交换产生的非规范转录物。

非规范转录包括系统地交换核苷酸的转录,也称为双射变换或摇摆器变换。Swinger转化A↔T+C↔G可以恢复在人类免疫缺陷病毒(HIV)相关的非霍奇金淋巴瘤中心性淋巴瘤中差异表达的9种未知RNA中的8种。鉴定出的RNA与具有已知抗HIV1或致癌活性的人类基因比对。通过回旋转换的转录功能的破坏潜在地可以避免抗病毒反应,并有助于诱发癌症。
更新日期:2020-08-04
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