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Rabies virus and Histoplasma suramericanum coinfection in a bat from southeastern Brazil.
Zoonoses and Public Health ( IF 2.4 ) Pub Date : 2019-11-21 , DOI: 10.1111/zph.12663
Benedito Donizete Menozzi 1 , Giselle Souza da Paz 1, 2 , Laís Moraes Paiz 3 , Hans Garcia Garces 1 , Brunna Mayla Vasconcelos Adorno 1 , Fernando Almeida-Silva 4 , Rosely Maria Zancope Oliveira 4 , Virgínia Bodelão Richini-Pereira 1, 5 , Jéssica Luana Chechi 1 , Eduardo Bagagli 1 , Sandra de Moraes Gimenes Bosco 1 , Helio Langoni 1
Affiliation  

Bats are essential to the global ecosystem, but their ability to harbour a range of pathogens has been widely discussed, as well as their role in the emergence and re-emergence of infectious diseases. This paper describes the first report of coinfection by two zoonotic agents, rabies virus (RABV) and the fungus Histoplasma suramericanum in a bat. The bat was from the Molossus molossus species, and it was found during the daytime in the hallway of a public psychiatric hospital in a municipality in São Paulo State, southeastern Brazil. RABV infection was diagnosed by the direct fluorescent antibody test and mouse inoculation test. The fungus was isolated by in vitro culture. Both diagnoses were confirmed by molecular techniques. Phylogenetic analysis showed that the fungus isolate had proximity to H. suramericanum in the Lam B clade, while the RABV isolate was characterized in the Lasiurus cinereus lineage. Since the M. molossus bat was found in a peri-urban transition area (urban/peri-urban), the possibility of cross-species transmission of this RABV lineage becomes more plausible, considering that this scenario may provide shelter for both M. molossus and L. cinereus. These are relevant findings since there has been an increase in bat populations in urban and peri-urban areas, particularly due to environmental modifications and anthropogenic impacts on their habitat. Thus, the detection of two zoonotic agents in a bat found in a public hospital should raise awareness regarding the importance of systematic surveillance actions directed towards bats in urban areas.

中文翻译:

来自巴西东南部的蝙蝠中的狂犬病病毒和suromericanum合并感染。

蝙蝠是全球生态系统必不可少的,但蝙蝠具有多种病原体的能力及其在传染病的出现和再出现中的作用已得到广泛讨论。本文描述了在蝙蝠中由两种人畜共患病因子狂犬病病毒(RABV)和真菌Histoplasma suramericanum共同感染的首次报道。蝙蝠是来自Molossus molossus物种的蝙蝠,白天在巴西东南部圣保罗州一家市立精神病医院的走廊上被发现。RABV感染通过直接荧光抗体测试和小鼠接种测试进行诊断。通过体外培养分离真菌。两种诊断均通过分子技术证实。系统发育分析表明,该真菌分离物与Lam B进化枝中的H. suramericanum接近,而RABV分离株的特征是灰灰猴谱系。由于在城郊过渡地区(城郊/城郊)发现了M. molossus蝙蝠,因此考虑到这种情况可能为M. Molossus提供庇护,该RABV血统跨物种传播的可能性变得更加合理。和灰葡萄。这些都是相关的发现,因为城市和城市周边地区的蝙蝠数量有所增加,特别是由于环境的改变和人为对其栖息地的影响。因此,在公立医院中发现的蝙蝠中有两种人畜共患病原菌的检测应提高人们对针对城市地区蝙蝠的系统性监视行动的重要性的认识。在城郊过渡地区(城郊/城郊)发现了蝙蝠科蝙蝠,这种RABV血统跨物种传播的可能性变得更加合理,因为考虑到这种情况可能为麝香罗汉果和灰质乳杆菌提供了庇护所。这些都是相关的发现,因为城市和城市周边地区的蝙蝠数量有所增加,特别是由于环境的改变和人为对其栖息地的影响。因此,在公立医院中发现的蝙蝠中有两种人畜共患病原菌的检测应提高人们对针对城市地区蝙蝠的系统性监视行动的重要性的认识。在城郊过渡地区(城郊/城郊)发现了蝙蝠科蝙蝠,这种RABV血统跨物种传播的可能性变得更加合理,因为考虑到这种情况可能为麝香罗汉果和灰质乳杆菌提供了庇护所。这些都是相关的发现,因为城市和城市周边地区的蝙蝠数量有所增加,特别是由于环境的改变和人为对其栖息地的影响。因此,在公立医院中发现的蝙蝠中有两种人畜共患病原菌的检测应提高人们对针对城市地区蝙蝠的系统性监视行动的重要性的认识。电影。这些都是相关的发现,因为城市和城市周边地区的蝙蝠数量有所增加,特别是由于环境的改变和人为对其栖息地的影响。因此,在公立医院中发现的蝙蝠中有两种人畜共患病原菌的检测应提高人们对针对城市地区蝙蝠的系统监视行动的重要性的认识。电影。这些都是相关的发现,因为城市和城市周边地区的蝙蝠数量有所增加,特别是由于环境的改变和人为对其栖息地的影响。因此,在公立医院中发现的蝙蝠中有两种人畜共患病原菌的检测应提高人们对针对城市地区蝙蝠的系统性监视行动的重要性的认识。
更新日期:2019-11-21
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