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Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?
Veterinary and Comparative Oncology ( IF 2.3 ) Pub Date : 2019-12-06 , DOI: 10.1111/vco.12555
Julius M Liptak 1
Affiliation  

There is no consensus on the definition of a complete histologic excision in veterinary oncology; many definitions have been used in various studies, but these have been arbitrarily selected with no apparent justification. The residual tumour classification scheme, where a complete histologic excision is defined as a histologic tumour‐free margin >0 mm, has been used for >40 years in human oncology by all of the major clinical staging organizations and is considered highly prognostic for the vast majority of malignant tumours in people. Because of the widespread use of the residual tumour classification scheme both clinically and in research studies, this standardized approach permits better communication between clinicians, an evidence‐based decision‐making process for adjuvant treatment options following surgical resection, minimizes exposing patients to unnecessary adjuvant treatments and a better ability to compare local tumour control for specific tumours between different studies. The adoption of the residual tumour classification scheme in veterinary oncology would likely achieve similar outcomes and minimize the prevalent confusion within the veterinary community, amongst both general practitioners and specialists, regarding the definition of what constitutes a complete histologic excision.

中文翻译:

组织学切缘和残余肿瘤分类方案:是时候在人体肿瘤学上使用经过验证的方案来标准化兽医肿瘤学中的切缘评估吗?

关于在兽医肿瘤学中完全组织学切除的定义尚无共识。在各种研究中已经使用了许多定义,但是这些选择是任意选择的,没有明显的理由。所有主要临床分期组织在人体肿瘤学中使用残余肿瘤分类方案,其中完整的组织学切除定义为组织学无肿瘤切缘> 0 mm,已在人类肿瘤学中应用了40多年,并且被认为对大量肿瘤预后良好。人中大多数为恶性肿瘤。由于残余肿瘤分类方案在临床和研究中均得到广泛使用,因此这种标准化方法可以使临床医生之间进行更好的沟通,这是手术切除后辅助治疗方案的循证决策过程,最大限度地减少了使患者接受不必要的辅助治疗的可能性,并在不同研究之间具有针对特定肿瘤比较局部肿瘤控制的更好能力。在兽医学上采用残留肿瘤分类方案可能会实现相似的结果,并在全科医生和专科医生之间就组成完整的组织学切除术的定义在兽医界内造成的普遍混乱最小化。
更新日期:2019-12-06
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