Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH () in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.

中文翻译：

---

新型基于炎症的生物标记物对肺动脉高压在慢性阻塞性肺疾病急性加重中的预测价值。

最近，人们对多种炎症指标的潜在临床应用越来越感兴趣，这些指标包括中性粒细胞与淋巴细胞之比（NLR），血小板与淋巴细胞之比（PLR）和全身免疫炎症指数（SII） 。这项研究旨在评估这些标志物是否可以作为慢性阻塞性肺疾病急性发作（AECOPD）患者肺动脉高压（PH）的早期指标。从2017年1月至2019年1月，我们共纳入185例患者作为回顾性研究。使用受试者工作特征曲线（ROC）和曲线下面积（AUC）评估这些生物标志物的临床意义，以预测AECOPD患者的PH 。根据多普勒超声心动图诊断PH的标准，将患者分为两组。研究组由101例合并PH的患者组成，对照组有84例患者。PH组的NLR，PLR和SII值显着高于AECOPD 1组（）。血液生物标志物水平与NT-proBNP水平呈正相关，而与PLR以外的其他估计的肺动脉收缩压（PASP）无显着相关性。NLR，PLR和SII值均与PH相关（）在单变量分析中，但不在多变量分析中。用于预测PH值的NLR的AUC为0.701，高于PLR和SII。以4.659作为NLR的临界值，灵敏度为81.2％，特异性为59.5％。总之，这些简单的标志物可能对AECOPD患者的PH预测有用。