Introduction: The review provides a comprehensive overview about applicability of serological detection of autoantibodies against aberrant glycans as cancer biomarkers.

Areas covered: Clinical usefulness of autoantibodies as cancer biomarkers is discussed for seven types of cancers with sensitivity and specificity of such biomarkers provided. Moreover, an option of using serological antibodies against a non-natural form of sialic acid – N-glycolylneuraminic acid (Neu5Gc), which is taken into our bodies together with red meat, as a potential cancer biomarker is discussed shortly as well.

Expert opinion: In the final part of the review, we discuss what measures need to be applied for selective implementation of autoantibody assays into a clinical practice. Moreover, we discuss key challenges ahead for reliable and robust detection of autoantibodies against aberrant glycans as biomarkers for disease diagnostics and for stratification of cancer patients.

简介：这篇综述全面概述了血清学检测抗异常聚糖的自身抗体作为癌症生物标志物的适用性。

涵盖的领域：讨论了自身抗体作为七种类型癌症的癌症生物标志物的临床实用性，并提供了此类生物标志物的敏感性和特异性。此外，还将讨论使用针对非天然形式的唾液酸-N-羟甘氨酰神经氨酸（Neu5Gc）的血清学抗体的一种选择，该抗体与红肉一起被带入我们的体内，作为潜在的癌症生物标记物。

专家意见：在本综述的最后部分，我们将讨论在临床实践中选择性实施自身抗体测定需要采取哪些措施。此外，我们讨论了针对可靠和可靠的针对异常聚糖的自身抗体检测的关键挑战，这些抗体是疾病诊断和癌症患者分层的生物标记。