Introduction: Schnitzler syndrome is an auto-inflammatory disease defined by chronic urticarial eruption and monoclonal gammopathy. 18F fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is often performed, but its utility in Schnitzler syndrome has not been specifically investigated. The aim of this study was to determine whether PET/CT is informative in the diagnosis and follow-up of Schnitzler syndrome relative to other imaging techniques, including bone scans.Patients and methods: Patients of this study were selected from the French cohort established by Néel et al. All patients with a diagnosis of Schnitzler syndrome (according to Strasbourg's and Lipsker's criteria) who had at least one PET/CT were included. Data were collected from medical records. PET/CT scans were all reviewed by a nuclear physician blinded to the clinical and imaging data.Results: Ten patients underwent at least one PET/CT scan and all had at least one 99mTechnetium bone scan during their follow-up. The most frequent PET/CT abnormalities were diffuse bone-marrow and/or increased femoral fluorodeoxyglucose uptake, but they did not correlate with disease activity. Conversely, bone-scan abnormalities, including mainly increased radiotracer uptake in long bones, appeared to strongly correlate with Schnitzler syndrome activity.Discussion: PET/CT does not appear to be useful for the diagnosis and follow-up of Schnitzler syndrome. However, bone scans appear to be more sensitive for diagnosis and may correlate with clinical activity. Bone scans may be well positioned to distinguish Schnitzler syndrome relapse from other aetiologies of bone, joint, or muscle pain.Conclusion: Bone scans may be favoured over PET/CT in Schnitzler syndrome.

中文翻译：

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18-F氟脱氧葡萄糖PET / CT和骨扫描对Schnitzler综合征的诊断价值。

简介：Schnitzler综合征是一种由慢性荨麻疹喷发和单克隆性丙种球蛋白病定义的自身炎症性疾病。经常进行18F氟脱氧葡萄糖正电子发射断层显像/计算机断层显像（PET / CT），但尚未专门研究其在Schnitzler综合征中的用途。这项研究的目的是确定相对于其他影像学技术（包括骨扫描），PET / CT对Schnitzler综合征的诊断和随访是否具有参考价值。患者和方法：本研究的患者选自法国Néel等。纳入所有诊断为Schnitzler综合征的患者（根据史特拉斯堡和Lipsker的标准），至少接受一次PET / CT检查。数据是从医疗记录中收集的。结果：10名患者接受了至少一次PET / CT扫描，并且在随访期间均进行了至少一次99mTechnetium骨扫描。最常见的PET / CT异常是弥漫性骨髓和/或股骨氟脱氧葡萄糖摄取增加，但它们与疾病活动性无关。相反，骨骼扫描异常（主要是长骨中放射性示踪剂摄取的增加）似乎与Schnitzler综合征的活动密切相关。讨论：PET / CT似乎对Schnitzler综合征的诊断和随访没有帮助。但是，骨扫描似乎对诊断更敏感，并且可能与临床活动相关。