Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer.

Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug.

Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml⁻¹) and 5.09% at the highest concentration (200μgml⁻¹).

Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.

目的：在这项研究中，合成了一种纳米海绵结构，该结构具有将姜黄素封装为模型多酚化合物的能力，并且由于其具有治疗癌症的能力而被广泛考虑的草药之一。

方法：采用FTIR，DSC和XRD技术确定了纳米海绵药物包合物的形成。

结果：包合物形成后，DSC和XRD图谱显示姜黄素具有增加的稳定性和降低的结晶度。封装效率为98％（w / w），并且装载量显着增加（184％w / w）。细胞毒性评估的结果表明对健康细胞系无细胞毒性，而对癌细胞有毒性。进行溶血试验以评价纳米海绵和复杂的血液相容性特性，结果表明在最低复杂浓度0.54％溶血（50μgml ^-1）和5.09％在最高浓度（200μgml ^-1）。

结论：因此，引入的系统可以作为药物输送系统在癌症治疗中被广泛考虑。