Increasingly, clinical infections are becoming recalcitrant or completely resistant to antibiotics treatment and multidrug resistance is rising alarmingly. Patients suffering from infections that used to be treated successfully by antibiotic regimens are running out of the treatment options. Bacteriophage (phage) therapy, long practiced in parts of Eastern Europe and the states of the former Soviet Union, is now being reevaluated as a treatment option complementary to and synergistic with antibiotic treatments. We discuss some current studies that have addressed synergistic killing activity between phages and antibiotics, the issues of treatment order and antibiotic class, and point to considerations that will have to be addressed by future studies. Overall, co-treatments with phages and antibiotics promise to extend the utility of antibiotics in current use. Nevertheless, a lot of work, both basic and clinical, remains to be done before such co-treatments become routine options in the hospital setting.

中文翻译：

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在一起更强？噬菌体-抗生素协同作用在噬菌体治疗临床应用中的观点。

越来越多的临床感染变得难以抵抗或完全对抗生素治疗产生抗药性，并且对多药的耐药性正在惊人地上升。过去曾通过抗生素疗法成功治疗过的感染患者已无治疗选择。噬菌体（噬菌体）疗法在东欧部分地区和前苏联各州已长期使用，现在正在重新评估其作为与抗生素治疗互补和协同的治疗选择。我们讨论了一些当前的研究，这些研究解决了噬菌体和抗生素之间的协同杀伤活性，治疗顺序和抗生素类别的问题，并指出了将来的研究必须解决的问题。总体，与噬菌体和抗生素的联合治疗有望扩大抗生素在当前使用中的效用。然而，在医院中，这种联合治疗成为常规选择之前，仍需进行许多基础和临床工作。