Follicular T-helper (T(FH) ) cells are a subset of CD4(+) T cells that is specialized to help B cells. Their capacity to give rise to enhanced T(FH) memory responses has not been documented. A study by Weber et al. [Eur. J. Immunol. 2012 42: 1981-1988] in this issue of the European Journal of Immunology addresses this question, and a picture is emerging from this and several other recent studies which suggests that the formation of memory T(FH) and of central memory (T(CM) ) cells are intimately bound and that the heterogeneity of what we currently call "T(FH) '' cells clouds this issue. In this Commentary, we discuss these complexities and ask what memory T(FH) cells are doing given that the germinal centers are a feature of primary, but not secondary immune responses.

中文翻译：

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T（FH）内存：更多（或更少）T（FH）？

滤泡性T辅助细胞（T（FH））是专门帮助B细胞的CD4（+）T细胞的子集。它们引起增强的T（FH）记忆反应的能力尚未得到证明。Weber等人的研究。[欧元。J.免疫。[2012 42：1981-1988]在《欧洲免疫学杂志》上解决了这个问题，此研究以及其他一些最近的研究也显示出一幅图景，这些图表明记忆T（FH）和中央记忆（T（ CM））细胞紧密相连，我们目前称为“ T（FH）”细胞的异质性掩盖了这个问题。在本评论中，我们讨论了这些复杂性，并询问给定T（FH）细胞在做什么记忆生发中心是原发性免疫反应的特征，而不是继发性免疫反应的特征。