Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models of insulin resistance" were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight.

中文翻译：

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脂质代谢紊乱和胰岛素抵抗的发病机理。

尽管异常的葡萄糖代谢定义了2型糖尿病（T2DM）并解决了其许多症状和并发症，但了解T2DM发病机理的努力越来越集中于脂质代谢紊乱。在这里，我们回顾了最近的人类研究，探索了脂肪酸/脂质代谢紊乱与胰岛素抵抗之间的机制联系。Nandi等在《生理学评论》中对“胰岛素抵抗的小鼠模型”进行了全面综述。在2004年，我们将集中精力进行涉及使用同位素和/或磁共振波谱学的人体研究，偶尔会借鉴可提供更多机械原理的小鼠模型。