CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addition to attracting B cells, BLC expression led to development of lymph node-like structures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemokine SLC. Development of these features was strongly dependent on B lymphocytes and on lymphotoxin alpha1beta2 and could be reversed by blocking lymphotoxin alpha1beta2. These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue.

中文翻译：

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胰岛中的BLC表达导致B细胞募集和淋巴毒素依赖性淋巴样新生。

B淋巴趋化因子（BLC）的受体CXCR5是Peyer斑块，腹股沟淋巴结和脾滤泡正常发育所必需的。为了在分离其他淋巴组织者中测试BLC的体内活性，产生了在胰岛中表达BLC的转基因小鼠。除了吸引B细胞外，BLC表达还导致形成淋巴结样结构，其中包含B和T细胞区，高内皮小静脉，基质细胞和趋化因子SLC。这些特征的发展强烈依赖于B淋巴细胞和淋巴毒素alpha1beta2，并且可以通过阻断淋巴毒素alpha1beta2来逆转。这些发现证实，BLC足以激活导致组织淋巴组织形成的事件的途径。