For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patch homing receptor integrin alpha4beta7: CD4+CD3- oligolineage progenitors and TCR gammadelta+ T cells. We show here that CD4+CD3- cells are lineage-restricted progenitors that express surface lymphotoxin-beta (LTbeta) and the chemokine receptor BLR1 and that can become natural killer cells, dendritic antigen-presenting cells, and follicular cells of unknown outcome, but these cells do not become T or B lymphocytes. Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture.

中文翻译：

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发育中的淋巴结收集的CD4 + CD3-LTbeta +细胞可以分化为APC，NK细胞和滤泡细胞，但不能分化为T或B细胞。

在小鼠胎儿淋巴结器官发生过程中的短暂时间内，淋巴结毛细血管后高内皮小静脉出人意料地表达了MAdCAM-1中的Peyer斑地址。该表达允许最初通过两个不寻常的淋巴细胞群体播种这种初生结构，这些淋巴细胞群体选择性表达Peyer's归巢受体整联蛋白alpha4beta7：CD4 + CD3-寡核苷酸祖细胞和TCRγ+ T细胞。我们在这里显示，CD4 + CD3-细胞是表达表面淋巴毒素-β（LTbeta）和趋化因子受体BLR1的谱系受限祖细胞，并且可以成为天然杀伤细胞，树突状抗原呈递细胞和未知结果的滤泡细胞，但是这些细胞不会变成T或B淋巴细胞。由于已经显示出淋巴毒素在淋巴器官发育中的必要性，