Polycations, mimicking activity of antibacterial peptides, belong to an important class of molecules investigated as a support or as an alternative to antibiotics. In this work, studies of modified linear amphiphilic statistical polymethyloxazoline (PMOX) and polyethyleneimine copolymers (PMOX_PEI) series are presented. Variation of PEI content in the structure results in controllable changes of polymeric aggregates zeta potential. The structure with the highest positive charge shows the best antimicrobial activity, well visible in tests against model Gram‐positive and Gram‐negative bacteria, fungi, and mycobacterium strains. The polymer toxicity is evaluated with MTT and hemolysis assay as a reference. Quartz crystal microbalance (QCM‐D) is used to investigate interaction between polycations and a model lipid membrane. Polymer activity correlates well with molecular structure, showing that amphiphilic component is altering polymer behavior in contact with the lipid bilayer.

中文翻译：

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两亲性聚甲基恶唑啉-聚乙烯亚胺共聚物：与脂质双层的相互作用和抗菌性能。

模仿阳离子抗菌肽活性的聚阳离子属于一类重要的分子，可作为一种支持物或替代抗生素。在这项工作中，研究了改性线性两亲统计聚甲基恶唑啉（PMOX）和聚乙烯亚胺共聚物（PMOX_PEI）系列。结构中PEI含量的变化导致聚合物聚集体ζ电势的可控变化。具有最高正电荷的结构显示出最佳的抗菌活性，在针对模型革兰氏阳性和革兰氏阴性细菌，真菌和分枝杆菌菌株的测试中非常明显。以MTT和溶血试验作为参考评估聚合物毒性。石英晶体微量天平（QCM‐D）用于研究聚阳离子与模型脂质膜之间的相互作用。