Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.

中文翻译：

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5-HT2AR和BDNF基因变异在饮食失调易感性中。

家庭和双胞胎研究的证据表明，对进食障碍（ED）的病因有遗传贡献，这一点已通过几种单核苷酸多态性（SNP）与这一组疾病的关联得到证实。先前的报道表明，血清素受体（5-HT2AR）和脑源性神经营养因子（BDNF）基因可能都与EDs易感性有关。为了提供有关这种关联的进一步证据，我们将注意力集中在这些基因中的两个SNP上，对由556名ED患者和355个对照（CTR）组成的大型意大利队列进行了遗传关联研究。获得的结果证实了5-HT2AR和BDNF基因之间存在关联以及对EDs的敏感性。