Immunological inflammatory reaction is one of the key links in the occurrence and development of post‐traumatic osteomyelitis after microbial invasion. Growing evidence suggests complex interactions between IFN‐γ and bone remodelling cells. However, potential association of IFN‐γ gene polymorphism with susceptibility to post‐traumatic osteomyelitis remains unclear. This study aimed to investigate the potential link between IFN‐γ +874T/A polymorphism and risk of developing post‐traumatic osteomyelitis. A total of 189 patients with post‐traumatic osteomyelitis and 200 healthy controls were enrolled for genotyping using the SNaPshot genotyping method. Statistically significant associations were found between the gene polymorphism and the risk of post‐traumatic osteomyelitis by dominant model (AA + AT vs. TT, OR = 1.820, p = .017) and heterozygous model (AT vs. TT, OR = 1.781, p = .029). Moreover, the frequency of mutant allele A was significantly higher in the patients than that in the healthy controls (15.07% vs. 9.25%, OR = 1.742, p = .013). IFN‐γ +874T/A polymorphism may contribute to the increased susceptibility to post‐traumatic osteomyelitis.

中文翻译：

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IFN-γ+874T/A 多态性增加对创伤后骨髓炎的易感性

免疫炎症反应是微生物侵袭后创伤后骨髓炎发生发展的关键环节之一。越来越多的证据表明 IFN-γ 和骨重塑细胞之间存在复杂的相互作用。然而，IFN-γ基因多态性与创伤后骨髓炎易感性之间的潜在关联仍不清楚。本研究旨在调查 IFN-γ +874T/A 多态性与发生创伤后骨髓炎的风险之间的潜在联系。共有 189 名创伤后骨髓炎患者和 200 名健康对照者被纳入使用 SNaPshot 基因分型方法进行基因分型。通过显性模型（AA + AT vs. TT，OR = 1.820，p = . 017）和杂合模型（AT vs. TT，OR = 1.781，p = .029）。此外，患者中突变等位基因 A 的频率显着高于健康对照组（15.07% vs. 9.25%，OR = 1.742，p = .013）。IFN-γ+874T/A 多态性可能导致对创伤后骨髓炎的易感性增加。