Evidence suggests accelerated aging mechanisms in bipolar disorder (BD), including DNA methylation (DNAm) aging in blood. However, it is unknown whether such mechanisms are also evident in the brain, in particular in association with other biological clocks. To investigate this, we interrogated genome‐wide DNAm in postmortem hippocampus from 32 BD‐I patients and 32 non‐psychiatric controls group‐matched for age and sex from the NIMH Human Brain Collection Core.

中文翻译：

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双相情感障碍中海马生物衰老加速。

有证据表明，双相情感障碍（BD）的加速衰老机制包括血液中的DNA甲基化（DNAm）衰老。但是，尚不清楚这种机制在大脑中是否也很明显，特别是与其他生物钟有关。为了对此进行调查，我们从NIMH人脑采集核心中对年龄和性别相匹配的32名BD-I患者和32个非精神病对照组的死后海马中的全基因组DNAm进行了研究。