The Frascati criteria for HIV-associated neurocognitive disorders (HAND; Antinori et al. 2007) outlines a classification scheme for functional decline that-despite being over a decade old-has not heretofore been examined systematically. Participants included 307 HIV+ and 183 HIV- participants who completed self-report, clinician-rated, and performance-based measures of functional status, along with neurocognitive, psychiatric, and medical/laboratory assessments. Using the Frascati criteria, we classified participants with (1) no functional declines, (2) mild functional declines, or (3) major functional declines. A multivariable logistic regression showed that HIV serostatus was associated with higher rates of major (33.2 vs. 13.7%) but not mild (38.8 vs. 31.7%) Frascati-defined functional decline. Within the HIV+ group, individuals with global neurocognitive impairment and affective disorders were at highest risk of Frascati-defined functional decline. Findings provide some empirical support for the sensitivity and validity of the Frascati criteria for functional declines in the context of HAND. Future work is needed to determine the reliability, stability, cross-cultural validity, and downstream health-related consequences of the Frascati-defined functional classifications.

中文翻译：

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操作性和评估功能的下降的弗拉斯卡蒂标准，以诊断成人的艾滋病毒相关的神经认知障碍。

HIV相关神经认知障碍的弗拉斯卡蒂标准（HAND； Antinori等，2007）概述了功能衰退的分类方案，尽管该功能衰退已超过十年，但迄今尚未进行系统的检查。参加者包括307名HIV +和183名HIV参与者，他们完成了自我报告，临床医师评估和基于绩效的功能状态评估，以及神经认知，精神病学和医学/实验室评估。使用Frascati标准，我们将参与者分为（1）没有功能下降，（2）轻度功能下降或（3）主要功能下降。多变量logistic回归显示，艾滋病毒血清状态与严重程度高（33.2 vs. 13.7％）而非轻度（38.8 vs. 31.7％）的弗拉斯卡蒂定义的功能下降相关。在HIV +组中，患有整体神经认知障碍和情感障碍的人患Frascati定义的功能衰退的风险最高。研究结果为HANS背景下功能下降的弗拉斯卡蒂标准的敏感性和有效性提供了一些经验支持。需要未来的工作来确定Frascati定义的功能分类的可靠性，稳定性，跨文化有效性以及与下游健康相关的后果。