Background Cystic fibrosis (CF) is now a recognised entity in India, with prevalence rates between 1/10,000 and 1/50,000. However, no data were available with regard to the profile of respiratory pathogens in the Indian setting. Materials and Methods The records of respiratory secretion bacterial cultures of children with CF in a tertiary care hospital in North India from January 2010 to December 2016 were reviewed. Culture data were evaluated; the organisms were noted and their antimicrobial susceptibilities were analysed. The microbiological profile and antimicrobial susceptibility pattern of CF patients were evaluated. Results A total of 445 samples from 146 children were processed, of which 246 (55%) samples showed bacterial growth. Mixed infections 48 (19.5%) were common in older children. Children aged 3-6 months (62.5%) showed the highest culture positivity. The most commonly isolated organisms were Pseudomonas aeruginosa (52.6%) and Staphylococcus aureus. Children with initial cultures positive for P. aeruginosa had 55% of their subsequent cultures showing polymicrobial infections. P. aeruginosa was most susceptible to ciprofloxacin (89%) and piperacillin-tazobactum (88%). Among the staphylococcal isolates, 38% were methicillin-resistant S. aureus (MRSA). The percentage of MRSA increased from 66% in 2010 to 75% in 2012, followed by a decline to 24% in 2016. Conclusions The pattern of airway colonisation in the Indian setting is different from the Caucasian population, and P. aeruginosa and Burkholderia cepacia complex appear early. Colonisation with P. aeruginosa benefits from therapy. In case of infection, care must be taken while initiating empiric therapy. It should be based on local antibiograms to prevent the emergence of resistant microbes.

中文翻译：

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对印度北部囊性纤维化儿童气道分泌物 7 年细菌学记录的回顾。


背景 囊性纤维化 (CF) 在印度现已成为公认的疾病，患病率在 1/10,000 至 1/50,000 之间。然而，没有关于印度环境中呼吸道病原体概况的数据。材料与方法回顾了2010年1月至2016年12月印度北部一家三级护理医院CF儿童的呼吸道分泌物细菌培养记录。评估培养数据；记录了这些微生物并分析了它们的抗菌敏感性。对 CF 患者的微生物学特征和抗菌药物敏感性模式进行了评估。结果 共处理了 146 名儿童的 445 份样本，其中 246 份（55%）样本显示细菌生长。混合感染 48 (19.5%) 在年龄较大的儿童中很常见。 3-6 个月大的儿童（62.5%）表现出最高的培养阳性率。最常见的分离微生物是铜绿假单胞菌（52.6%）和金黄色葡萄球菌。初次培养铜绿假单胞菌呈阳性的儿童，55% 的后续培养显示多种微生物感染。铜绿假单胞菌对环丙沙星 (89%) 和哌拉西林-他唑巴坦 (88%) 最敏感。在葡萄球菌分离株中，38% 是耐甲氧西林金黄色葡萄球菌 (MRSA)。 MRSA 的百分比从 2010 年的 66% 上升至 2012 年的 75%，随后在 2016 年下降至 24%。 结论 印度人的气道定植模式与高加索人群不同，铜绿假单胞菌和洋葱伯克霍尔德菌也不同。复杂出现得早。铜绿假单胞菌的定植受益于治疗。如果发生感染，开始经验治疗时必须小心。应以当地抗菌谱为基础，以防止耐药微生物的出现。