BackgroundThe aim of the current study was to determine if 4 weeks of consumption of Bang® Pre-Workout Master Blaster® (BMB; Vital Pharmaceuticals Inc., Weston, FL) combined with resistance training resulted in greater increases in muscle mass and maximal strength compared with resistance training combined with placebo (PLA). Additionally, we aimed to determine if BMB ingestion combined with resistance training preferentially altered resting skeletal muscle expression of microRNAs (miRs) or resting serum insulin-like growth factor (IGF-1).MethodsSixteen recreationally-active men completed the study. The study employed a block-randomized, double-blind, placebo-controlled, parallel design. Participants completed two testing sessions separated by 4 weeks of resistance exercise combined with daily supplementation of BMB or PLA. At each testing session, hemodynamics, body composition, and muscle and blood samples were obtained followed by strength assessments of the lower- and upper-body via measurement of squat and bench press one-repetition maximum (1-RM), respectively. A separate general linear model was utilized for analysis of each variable to determine the effect of each supplement (between-factor) over time (within-factor) using an a priori probability level of ≤0.05.ResultsNo significant effects were observed for dietary intake, hemodynamics, fat mass, body fat percentage, or serum IGF-1. A greater increase in total body mass (3.19 kg, 95% CI, 1.98 kg, 4.40 kg vs. 0.44 kg, 95% CI, − 0.50 kg, 1.39 kg) and lean body mass (3.15 kg, 95% CI, 1.80 kg, 4.49 kg vs. 0.89 kg, 95% CI, − 0.14 kg, 1.93 kg) was observed for the BMB group compared with PLA (p < 0.01). A significant increase over time was observed for miR-23a (p = 0.02) and miR-23b (p = 0.05) expression. A greater increase in squat 1-RM was observed for the BMB group (23.86 kg, 95% CI, 16.75 kg, 30.97 kg) compared with the PLA group (14.20 kg, 95% CI, 7.04 kg, 21.37 kg, p = 0.04).ConclusionsBMB supplementation combined with resistance exercise training for 4 weeks resulted in superior adaptations in maximal strength and LBM compared with resistance training with a placebo. No adverse resting hemodynamic or clinical blood safety markers were observed as a result of BMB supplementation. The superior outcomes associated with BMB supplementation could not be explained by resting serum IGF-1 or the skeletal muscle miRs measured, although resting miR-23a and miR-23b expression both increased as a result of resistance training.

中文翻译：

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Bang® Pre-Workout Master Blaster® 结合 4 周阻力训练对男性瘦体重、最大力量、miRNA 表达和血清 IGF-1 的影响：一项随机、双盲、安慰剂对照试验

背景本研究的目的是确定服用 4 周的 Bang® Pre-Workout Master Blaster®（BMB；Vital Pharmaceuticals Inc., Weston, FL）与阻力训练相结合是否会导致肌肉质量和最大力量的更大增加。阻力训练结合安慰剂（PLA）。此外，我们旨在确定 BMB 摄入与阻力训练相结合是否优先改变静息骨骼肌微 RNA (miRs) 或静息血清胰岛素样生长因子 (IGF-1) 的表达。方法 16 名休闲活跃的男性完成了这项研究。该研究采用了块随机、双盲、安慰剂对照、平行设计。参与者完成了两个测试阶段，间隔 4 周的阻力运动结合每日补充 BMB 或 PLA。在每个测试阶段，获得血液动力学、身体成分以及肌肉和血液样本，然后分别通过测量深蹲和卧推最大重复次数 (1-RM) 来评估下半身和上半身的力量。使用单独的通用线性模型分析每个变量，以确定每个补充剂（因子间）随时间（因子内）的影响，使用 ≤ 0.05 的先验概率水平。 结果 未观察到膳食摄入量的显着影响，血流动力学、脂肪量、体脂百分比或血清 IGF-1。总体重（3.19 kg, 95% CI, 1.98 kg, 4.40 kg vs. 0.44 kg, 95% CI, − 0.50 kg, 1.39 kg）和瘦体重（3.15 kg, 95% CI, 1.80 kg）增加幅度更大与 PLA 相比，BMB 组观察到 4.49 kg vs. 0.89 kg，95% CI，- 0.14 kg，1.93 kg）（p < 0.01）。观察到 miR-23a (p = 0.02) 和 miR-23b (p = 0.05) 表达随时间显着增加。与 PLA 组（14.20 kg，95% CI，7.04 kg，21.37 kg，p = 0.04）相比，观察到 BMB 组（23.86 kg，95% CI，16.75 kg，30.97 kg）的深蹲 1-RM 增加更多).结论 与使用安慰剂的阻力训练相比，BMB 补充剂与 4 周的阻力运动训练相结合，在最大力量和 LBM 方面具有更好的适应性。由于补充 BMB，没有观察到不利的静息血流动力学或临床血液安全标志物。尽管静息 miR-23a 和 miR-23b 表达均因阻力训练而增加，但与 BMB 补充相关的优异结果无法通过静息血清 IGF-1 或测量的骨骼肌 miRs 来解释。