Stem cells in skeletal muscle growth and regeneration in amniotes and teleosts: Emerging themes.,WIREs Mechanisms of Disease

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Stem cells in skeletal muscle growth and regeneration in amniotes and teleosts: Emerging themes.
WIREs Mechanisms of Disease ( IF 4.6 ) Pub Date : 2019-11-19 , DOI: 10.1002/wdev.365
Avnika A Ruparelia _{1,

2} , Dhanushika Ratnayake _{1,

2} , Peter D Currie _{1,

2}

Affiliation

Skeletal muscle is a contractile, postmitotic tissue that retains the capacity to grow and regenerate throughout life in amniotes and teleost. Both muscle growth and regeneration are regulated by obligate tissue resident muscle stem cells. Given that considerable knowledge exists on the myogenic process, recent studies have focused on examining the molecular markers of muscle stem cells, and on the intrinsic and extrinsic signals regulating their function. From this, two themes emerge: firstly, muscle stem cells display remarkable heterogeneity not only with regards to their gene expression profile, but also with respect to their behavior and function; and secondly, the stem cell niche is a critical regulator of muscle stem cell function during growth and regeneration. Here, we will address the current understanding of these emerging themes with emphasis on the distinct processes used by amniotes and teleost, and discuss the challenges and opportunities in the muscle growth and regeneration fields.

中文翻译：

羊膜和硬骨中骨骼肌中干细胞的生长和再生：新兴主题。

骨骼肌是一种收缩的有丝分裂后组织，在羊膜和硬骨动物的整个生命过程中都具有生长和再生的能力。肌肉的生长和再生都受专营组织驻留的肌肉干细胞的调节。鉴于对肌生成过程已有大量知识，最近的研究集中在检查肌肉干细胞的分子标记以及调节其功能的内在和外在信号上。由此，出现了两个主题：首先，肌肉干细胞不仅在基因表达方面而且在行为和功能方面都表现出显着的异质性。其次，干细胞生态位是肌肉干细胞在生长和再生过程中的关键调节因子。这里，

更新日期：2019-11-19

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