PROBLEM Omega-3 and omega-6 fatty acids can be endogenously converted into mediators with pro-inflammatory (eg, leukotriene B4/LTB4) or anti-inflammatory/pro-resolving activities (eg, resolvin D1/RvD1 and maresin 1/MaR1). Recent data indicate an imbalance of LTB4 and MaR1 levels in pre-eclampsia (PE), but the relative production of these mediators, including RvD1, and the role of these mediators in the disease pathogenesis remain unclear. Therefore, this study aimed to investigate the plasma levels of LTB4, RvD1, and MaR1 in pregnant women with or without PE and non-pregnant controls and their association with clinical/laboratory parameters of PE women. METHOD OF STUDY LTB4, RvD1, and MaR1 plasma levels were measured by competitive enzyme immunoassay in 19 non-pregnant, 20 normotensive pregnant, and 21 PE women. RESULTS Plasma concentrations of LTB4 were higher and RvD1 were lower in PE women than in normotensive pregnant women, who presented higher levels of LTB4 and similar levels of RvD1 to non-pregnant women. MaR1 levels did not differ among the groups. Pre-eclampsia women had decreased RvD1/LTB4 and MaR1/LTB4 ratios. Considering only the PE group, positive correlations were observed among all the mediators tested, between LTB4 and white blood cell count and between RvD1 and creatinine levels. However, all lipid mediators correlated negatively with body mass index before pregnancy. LTB4 also correlated negatively with maternal age. CONCLUSION Our findings suggest that the PE state results in systemic overproduction of LTB4 in relation to RvD1 and MaR1, and that these lipid mediators may be involved with the disease pathogenesis.

中文翻译：

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子痫前期与血浆中resolvin D1和maresin 1与白三烯B4的比率降低有关。

问题Omega-3和omega-6脂肪酸可以内源性地转化为具有促炎作用（例如白三烯B4 / LTB4）或具有消炎/促分解作用（例如resolvin D1 / RvD1和maresin 1 / MaR1）的介质。 。最近的数据表明先兆子痫（PE）中LTB4和MaR1的水平失衡，但是这些介体（包括RvD1）的相对产生以及这些介体在疾病发病机理中的作用仍不清楚。因此，本研究旨在调查有或没有PE和非妊娠控制的孕妇血浆中LTB4，RvD1和MaR1的血浆水平及其与PE妇女临床/实验室参数的关系。研究方法通过竞争性酶免疫法测定19例未怀孕，20例血压正常的孕妇和21例PE妇女的LTB4，RvD1和MaR1血浆水平。结果与正常血压的孕妇相比，PE妇女的血浆LTB4较高，RvD1较低，而正常血压的孕妇中LTB4的水平较高，而RvD1的水平与非孕妇相似。两组间的MaR1水平没有差异。子痫前期妇女的RvD1 / LTB4和MaR1 / LTB4比率降低。仅考虑PE组，在所有测试的介体之间，LTB4与白细胞计数之间以及RvD1与肌酐水平之间观察到正相关。但是，所有脂质介体与妊娠前体重指数呈负相关。LTB4也与产妇年龄负相关。结论我们的研究结果表明PE状态导致LTB4相对于RvD1和MaR1的系统性过度生产，并且这些脂质介体可能与疾病的发病机制有关。