Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.,Immunogenetics

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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.
Immunogenetics ( IF 2.9 ) Pub Date : 2019-10-17 , DOI: 10.1007/s00251-019-01132-x
Natasja G de Groot ₁ , Nel Otting ₁ , Giuseppe Maccari _{2,

3} , James Robinson _{3,

4} , John A Hammond ₂ , Antoine Blancher _{5,

6} , Bernard A P Lafont ₇ , Lisbeth A Guethlein ₈ , Emily E Wroblewski ₉ , Steven G E Marsh _{3,

4} , Takashi Shiina ₁₀ , Lutz Walter ₁₁ , Linda Vigilant ₁₂ , Peter Parham ₈ , David H O'Connor ₁₃ , Ronald E Bontrop _{1,

14}

Affiliation

Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands.
The Pirbright Institute, Pirbright, Woking, Surrey, UK.
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK.
UCL Cancer Institute, University College London, Royal Free Campus, Pond Street, Hampstead, London, NW3 2QG, UK.
Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Paul Sabatier (UPS), 31000, Toulouse, France.
Laboratoire d'Immunologie, CHU de Toulouse, Institut Fédératif de Biologie, Hôpital Purpan, 330 Avenue de Grande Bretagne, TSA40031, 31059, Toulouse CEDEX 9, France.
Viral Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Department of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
Department of Anthropology, Washington University, St Louis, MO, 63130, USA.
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Hiratsuka-shi, Kanagawa, Japan.
Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077, Göttingen, Germany.
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH, Utrecht, The Netherlands.

The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database.

中文翻译：

2019年命名报告：大猿和小猿以及旧世界和新世界猴子的主要组织相容性复杂基因和等位基因。

主要的组织相容性复合体（MHC）对于颌骨脊椎动物的先天性和适应性免疫反应至关重要。MHC的特征是高基因密度，基因拷贝数变异和等位基因多态性。由于猿和猴子是人类最亲近的近亲，因此在进化，生物医学和保护生物学的背景下，对这些非人类灵长类动物（NHP）的MHC进行了深入研究。免疫多态性数据库（IPD）-MHC NHP数据库（IPD-MHC NHP），用于管理大，小猿以及旧世界和新世界猴子的MHC数据，已经升级。数据库的负责人负责为新发现的等位基因提供正式名称。此命名报告更新了2012年报告，

更新日期：2020-04-21

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