Plasmin, a relatively unspecific trypsin‐like serine protease, is involved in many physiological and pathological conditions, particularly in dermatoses with barrier impairment. It is secreted as the inactive zymogen plasminogen and is activated to plasmin by plasminogen activators, such as urokinase. There still exists a paucity of data on the precise localization of epidermal plasmin(ogen) within the epidermis and the stratum corneum. The aim of the present study was to get information about its origin and ultrastructural localization within normal human epidermis.

中文翻译：

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纤溶酶（原）在正常人表皮的终末分化层中的表达和超微结构定位。

纤溶酶是一种相对非特异性的胰蛋白酶样丝氨酸蛋白酶，与许多生理和病理状况有关，尤其是在屏障受损的皮肤病中。它作为无活性的酶原纤溶酶原分泌，并被纤溶酶原激活剂如尿激酶激活为纤溶酶。仍然缺乏关于表皮纤溶酶（原）在表皮和角质层内的精确定位的数据。本研究的目的是获取有关其在正常人表皮内的起源和超微结构定位的信息。