Recently, manuscripts that use bioinformatics tools to convert proteins and other biological materials into music have appeared in several journals. The authors claim that this type of studies adds joy to education of life sciences and attract public attention to biochemistry education along with other uses. We thought the reverse of the process might also be possible for the purpose. We converted notes into amino acids depending on the decreasing hydrophobicity and by using the famous nursery song “Twinkle, Twinkle, Little Star” notes, a hypothetical protein sequence was obtained. Three‐dimensional structures were modeled by I‐Tasser Protein Structure and Function Prediction server and the structure of the possible models were investigated. This Science, Technology, Engineering, Arts and Math (STEAM) approach may bring fun to protein structure education. © 2019 International Union of Biochemistry and Molecular Biology, 47(6):669–671, 2019.

中文翻译：

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氨基酸序列的音符：研究蛋白质结构的 STEAM 方法

最近，使用生物信息学工具将蛋白质和其他生物材料转换成音乐的手稿出现在几家期刊上。作者声称，这种类型的研究为生命科学教育增添了乐趣，并吸引了公众对生物化学教育以及其他用途的关注。我们认为，为了达到这个目的，过程的逆向也是可能的。我们根据疏水性的降低将音符转换为氨基酸，并通过使用著名的儿歌“Twinkle，Twinkle，Little Star”音符，获得了假设的蛋白质序列。通过I-Tasser蛋白质结构和功能预测服务器对三维结构进行建模，并对可能的模型结构进行了研究。这个科学、技术、工程、艺术和数学（STEAM）方法可能会给蛋白质结构教育带来乐趣。© 2019 国际生物化学与分子生物学联盟，47(6):669–671，2019。