Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and characterization of several positron emission tomography radioligands used to detect tau pathophysiology in vivo, and how these ligands are being used in clinical aging and neurodegenerative disease research with a focus on imaging tau aggregates in Alzheimer's disease.

中文翻译：

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AD分子：利用正电子发射断层显像对tau聚集体进行成像。

在几种神经退行性疾病中观察到tau蛋白的病理性聚集体，可用于诊断和分期诊断疾病。正电子发射断层扫描放射配体的最新进展允许检测活人中聚集的tau蛋白。本章描述了几种用于体内检测tau病理生理的正电子发射断层显像放射配体的开发和表征，以及这些配体如何用于临床衰老和神经退行性疾病研究，重点是对阿尔茨海默氏病中tau聚集体的成像。