当前位置: X-MOL 学术Trends Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae.
Trends in Immunology ( IF 13.1 ) Pub Date : 2001-06-01 , DOI: 10.1016/s1471-4906(01)01926-3
C M Snapper 1 , Y Shen , A Q Khan , J Colino , P Zelazowski , J J Mond , W C Gause , Z Q Wu
Affiliation  

Studies have indicated that purified soluble polysaccharide antigens can elicit T cell-independent Ig responses in vivo, although these responses can be modulated by T cells in a noncognate manner. Relatively little is known, however, concerning the parameters that regulate polysaccharide-specific, as well as protein-specific, Ig isotype responses to an intact extracellular bacterium. Using the murine in vivo humoral response to intact Streptococcus pneumoniae as a model it can be shown that CD4+ T-cell receptor alphabeta+ T cells deliver help for both polysaccharide- and protein-specific Ig responses. However, these responses differ fundamentally in their mechanism of action.

中文翻译:

不同类型的T细胞有助于诱导对肺炎链球菌的体液免疫反应。

研究表明,纯化的可溶性多糖抗原可以在体内引起非T细胞依赖性Ig反应,尽管这些反应可以由T细胞以非同源方式调节。然而,关于调节对完整的细胞外细菌的多糖特异性以及蛋白质特异性Ig同种型应答的参数知之甚少。使用鼠对完整肺炎链球菌的体内体液反应作为模型,可以证明CD4 + T细胞受体字母+ T细胞可为多糖和蛋白质特异性Ig反应提供帮助。但是,这些反应的作用机理根本不同。
更新日期:2019-11-01
down
wechat
bug