A dogma has persisted for over two decades that food allergens are more stable to digestion compared with non-allergenic proteins. This belief has become enshrined in regulations designed to assess the allergenic risk of novel food proteins. While the empirical evidence accumulated over the last 20+ years has largely failed to confirm a correlation between digestive stability and the allergenic status of proteins, even those who accept this finding often assert that this shortfall is the result of faulty assay design rather than lack of causality. Here, we outline why digestive stability may not in fact correlate with allergenic potential.

中文翻译：

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证据与预测蛋白质过敏性的消化稳定性相反。


二十多年来，人们一直认为食物过敏原比非过敏性蛋白质更容易消化。这一信念已被纳入旨在评估新型食品蛋白质过敏风险的法规中。虽然过去 20 多年积累的经验证据在很大程度上未能证实消化稳定性与蛋白质过敏状态之间的相关性，但即使是那些接受这一发现的人也经常断言，这种不足是检测设计错误的结果，而不是缺乏因果关系。在这里，我们概述了为什么消化稳定性实际上可能与潜在的过敏性无关。