Based on numerous findings of an abnormal laterality in schizophrenia disorder, we hypothesized that handedness and lateral preferences may affect the age at onset in schizophrenia patients. Two samples of schizophrenia patients, the first a sample of 34 right-handers and 42 left-handers and a replication set of 84 right-handers, were examined with regard to age at onset considering handedness and the four Luria’s signs (arm folding, hand clasping, familial sinistrality and eye dominance) as well as gender. The association between these parameters and age at onset was investigated by means of multiple regression analysis. Our analyses revealed that right-handers with right arm folding and left-handers with left arm folding showed an early age at onset, while in the late age at onset the opposite preferences prevailed. Apart from arm folding, signs of ambilaterality, i.e., left eye dominance in right-handers and familial sinistrality in left-handers were additional predictors for an early age at onset. Remarkably, all observations found in the first right-handed sample were confirmed in the right-handed replication set. We conclude that among the many different factors specific lateral preferences should also be considered in assessing patients who are at risk of psychosis.

基于在精神分裂症中偏侧性异常的大量发现，我们假设惯性和侧偏会影响精神分裂症患者的发病年龄。考虑到惯用手法和四个Luria's征象（手臂折叠，手掌弯曲），检查了两个精神分裂症患者样本，第一个样本为34个右撇子和42个左撇子，以及84个右撇子的复制集。扣人心弦，家族性的鼻窦病和眼睛主导地位）以及性别。通过多元回归分析研究了这些参数与发病年龄之间的关联。我们的分析表明，右手折叠的右撇子和左手折叠的左撇子在发病年龄较早，而在发病晚期则相反。除了手臂折叠 偏执的迹象，即右撇子的左眼优势和左撇子的家族性鼻窦病是发病初期的其他预测因素。值得注意的是，在右手复制集中确认了在第一个右手样本中发现的所有观察结果。我们得出结论，在评估有精神病风险的患者时，还应考虑特定的横向偏爱，这是许多不同因素中的一个。