Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system function, and fundamental changes in behaviors such as learning, memory, and social interactions. Human cohort studies reveal correlations between maternal/fetal exposure to endocrine disruptors and incidence of neurodevelopmental disorders. Here, we summarize the major literature findings of endocrine disruption of neurodevelopment and concomitant changes in behavior by four major endocrine disruptor classes:bisphenol A, polychlorinated biphenyls, organophosphates, and polybrominated diphenyl ethers. We specifically review studies of gestational and/or lactational exposure to understand the effects of early life exposure to these compounds and summarize animal studies that help explain human correlative data.

中文翻译：

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妊娠暴露于常见的内分泌干扰化学物质及其对神经发育和行为的影响。

破坏内分泌的化学物质在我们的环境中很常见，并作用于激素系统和信号传导途径，以改变生理稳态。妊娠暴露会破坏发育程序，永久改变组织，影响持续到成年。大脑是发育性内分泌破坏的关键目标，其导致激素信号的神经内分泌控制改变，神经系统功能的神经递质控制改变以及行为的根本变化，例如学习，记忆和社交互动。人类队列研究揭示了母体/胎儿对内分泌干扰物的暴露与神经发育障碍的发生率之间的相关性。这里，我们总结了四种主要的内分泌干扰物类别：双酚A，多氯联苯，有机磷酸酯和多溴联苯醚，这些文献对内分泌破坏神经发育和行为伴随变化的主要文献发现进行了研究。我们专门回顾了妊娠和/或哺乳期暴露的研究，以了解生命早期暴露于这些化合物的影响，并总结了有助于解释人类相关数据的动物研究。