The genetic and/or antigenic differences between street rabies virus (RABV) and vaccine strains could potentially affect effectiveness of rabies vaccines. As such, it is important to continue monitoring the glycoprotein (G) of the street isolates. All RABVG sequences in public database were retrieved and analysed. Using a pseudovirus system, we investigated 99 naturally occurring mutants for their reactivities to well-characterized neutralizing monoclonal antibodies (mAbs) and vaccine-induced antisera. A divergence in G sequences was found between vaccine strains and recent street isolates, with mutants demonstrating resistance to neutralizing mAbs and vaccine-induced antibodies. Moreover, antigenic variants were observed in a wide range of animal hosts and geographic locations, with most of them emerging since 2010. As the number of antigenic variants has increased in recent years, close monitoring on street isolates should be strengthened.

中文翻译：

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最近的街头狂犬病毒的抗原变异。

狂犬病街头狂犬病毒（RABV）和疫苗株之间的遗传和/或抗原差异可能会影响狂犬病疫苗的有效性。因此，继续监测街头分离株的糖蛋白（G）非常重要。检索并分析了公共数据库中的所有RABVG序列。使用伪病毒系统，我们调查了99种天然突变体与特征明确的中和单克隆抗体（mAb）和疫苗诱导的抗血清的反应性。在疫苗株和最近的街头分离株之间发现了G序列的差异，突变株显示出对中和mAb和疫苗诱导的抗体的抗性。此外，在广泛的动物宿主和地理位置观察到抗原变体，其中大多数是自2010年以来出现的。