In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of immune system could be influenced by genetic factors. The aim of the present study was to investigate the distribution of alleles of polymorphisms relevant for chronic periodontitis in a sample of adult subjects affected by chronic PD. The present study was conducted with sample collected in Italian private practice offices from January 2013 to December 2017. The sample included 744 adult patients diagnosed with chronic periodontitis. The inclusion criteria were as follows: age > 18 years, diagnosis of chronic PD. The diagnosis of chronic periodontitis was based on the criteria established by the American Academy of Periodontology. No significant difference in allele distribution among patients from different Italian regions was found. Results, supporting absence of population heterogeneity for the investigated polymorphisms in Italy, suggest similar effect in periodontitis etiology.

中文翻译：

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对受慢性牙周病影响的意大利大样本受试者中 IL6、IL10 和 VDR 等位基因分布的评估。


近几十年来，人们对细菌免疫反应在慢性牙周病（PD）发病机制中所起的作用进行了长期研究。尽管从临床角度来看，足够的口腔卫生对于确保宿主对感染做出令人满意的反应至关重要，但免疫系统反应的调节可能会受到遗传因素的影响。本研究的目的是调查患有慢性牙周病的成年受试者样本中与慢性牙周炎相关的多态性等位基因的分布。本研究采用 2013 年 1 月至 2017 年 12 月在意大利私人诊所收集的样本进行。样本包括 744 名被诊断患有慢性牙周炎的成年患者。纳入标准如下：年龄> 18岁，诊断为慢性PD。慢性牙周炎的诊断基于美国牙周病学会制定的标准。来自意大利不同地区的患者等位基因分布没有发现显着差异。结果支持意大利所调查的多态性不存在群体异质性，表明牙周炎病因学中存在类似的效果。