In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%-25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%-4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti-thyroid autoantibodies, antinuclear, anti-transglutaminase, and anti-endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.

中文翻译：

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自身抗体在反复妊娠流产中的致病作用。

在本文中，我们回顾了最近的研究，该研究调查了大多数研究的自身抗体与复发性流产之间的致病关系。怀孕流失是常见的产科并发症，约占所有临床公认的妊娠的15％-25％。妊娠流产的复发确定了一个独特的临床实体，即反复流产（RPL），影响约2％-4％的夫妻。RPL涉及多个因素，包括年龄，染色体异常，子宫异常，血栓形成性疾病，内分泌病变，激素和代谢性疾病，感染，精子质量和生活方式问题。自身抗体在RPL中的作用仅部分确定。在某些情况下（抗磷脂抗体[aPL]），它们的参与已得到充分证实。在其他情况下（抗甲状腺自身抗体，抗核，抗转谷氨酰胺酶和抗肌内膜抗体），尽管有很多（尽管不是完全结论性的）证据仍然强烈争论，但有力证据表明可能参与了RPL。需要进一步的广泛研究来确定或排除其实际作用。