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Embryonic Fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA.
Ecotoxicology ( IF 2.4 ) Pub Date : 2019-10-16 , DOI: 10.1007/s10646-019-02116-z
Savannah J Volkoff 1 , Joshua S Osterberg 1 , Nishad Jayasundara 1, 2 , Ellen Cooper 1 , Heileen Hsu-Kim 3 , Laura Rogers 3 , Gretchen E Gehrke 3 , Saro Jayaraman 4 , Richard T Di Giulio 1
Affiliation  

Sites along the Elizabeth River are contaminated with polycyclic aromatic hydrocarbons (PAHs) from historical creosote production and other industrial processes. Previous studies have demonstrated that Atlantic killifish collected from sites throughout the Elizabeth River display resistance to the teratogenic effects of PAH-exposure in a manner commensurate with sediment PAH concentrations. The current study characterized various chemical pollutants in sediment and investigated the effects of aqueous sediment extracts from sites along the Elizabeth River to the cardiac development of Atlantic killifish embryos from fish collected from an uncontaminated reference site. Embryonic cardiac deformities were more prevalent after exposure to extracts from sites with high PAH loads. However, activation of cytochrome P4501A, a gene up-regulated by PAH-induction of the aryl hydrocarbon receptor and measured using an in ovo EROD assay, did not consistently increase with PAH concentrations. This work further characterizes sediments in the Elizabeth River, as well as provides insight into the evolutionary pressures at each ER site.

中文翻译:

弗吉尼亚州伊丽莎白河不同污染地点的沉积物提取物对胚胎底Fund的异质反应。

伊丽莎白河沿岸的站点被历史上的杂酚油生产和其他工业过程中的多环芳烃(PAH)污染。先前的研究表明,从伊丽莎白河沿岸的各个地点收集到的大西洋鲑鱼以与沉积物中PAH浓度相当的方式显示出对PAH暴露致畸作用的抵抗力。当前的研究对沉积物中的各种化学污染物进行了表征,并研究了伊丽莎白河沿岸站点的含水沉积物提取物对从未经污染的参考站点收集的鱼类的大西洋kill鱼胚胎的心脏发育的影响。暴露于高PAH负荷部位的提取物后,胚胎心脏畸形更为普遍。但是,细胞色素P4501A的激活 通过芳烃受体的PAH诱导上调并使用ovo EROD测定法测量的基因,并不随PAH浓度持续增加。这项工作进一步表征了伊丽莎白河中的沉积物,并提供了对每个ER站点演化压力的见解。
更新日期:2019-11-01
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