Oxygen-sensing implants, composed of paramagnetic microcrystals embedded in a biocompatible polymer, are increasingly being used for electron paramagnetic resonance (EPR) oximetry in animal models and human subjects. The implants are stable and designed to stay in the tissues for indefinite periods. However, it is not known whether the crystals that may be exposed on the surface of the implants or leached out from the implants will induce cytotoxicity thereby compromising their biocompatibility over the long term. The goal of the current study was to evaluate the cytotoxicity of the implants and crystalline particulates under in vitro conditions. Apoptosis and cell viability studies were performed using L6, a rat muscle cell line and AsPC-1, a cancer cell line derived from human pancreatic adenocarcinoma. The results indicated that neither the intact implants nor their components elicit cytotoxicity, thus establishing their biocompatibility for use in human subjects.

中文翻译：

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氧敏感顺磁性植入物的生物相容性。

由嵌入生物相容性聚合物中的顺磁性微晶组成的氧感测植入物正越来越多地用于动物模型和人类受试者的电子顺磁共振（EPR）血氧测定。植入物很稳定，可以在组织中无限期地停留。然而，尚不清楚可能暴露在植入物表面上或从植入物浸出的晶体是否会诱导细胞毒性，从而长期损害其生物相容性。当前研究的目的是评估体外条件下植入物和晶体颗粒的细胞毒性。使用大鼠肌肉细胞系L6和源自人胰腺腺癌的癌细胞系AsPC-1进行凋亡和细胞活力研究。