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A cortical microvascular structure in vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration, and non‐demented controls: a sign of angiogenesis due to brain ischaemia?
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2019-05-09 , DOI: 10.1111/nan.12552
H Ek Olofsson 1 , E Englund 1
Affiliation  

We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a ‘raspberry’, referring to its appearance under a bright‐field microscope. We hypothesized that raspberries form through angiogenesis due to some form of brain ischaemia or hypoperfusion. The aims of this study were to quantify raspberry frequency within the cerebral cortex according to diagnosis (vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration and nondemented controls) and brain regions (frontal, temporal, parietal and occipital cortices, regardless of diagnosis).

中文翻译:

血管性痴呆、阿尔茨海默病、额颞叶变性和非痴呆对照中的皮质微血管结构:脑缺血导致血管生成的迹象?

我们观察到大脑皮层中的微血管结构,据我们所知,以前没有描述过。我们称这种结构为“覆盆子”,指的是它在明场显微镜下的外观。我们假设覆盆子是由于某种形式的脑缺血或灌注不足而通过血管生成形成的。本研究的目的是根据诊断(血管性痴呆、阿尔茨海默病、额颞叶变性和非痴呆对照)和大脑区域(额叶、颞叶、顶叶和枕叶皮质,无论诊断如何)量化大脑皮层内的覆盆子频率。
更新日期:2019-05-09
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