ABSTRACT

Occupational pesticides exposure rises health concern due to genotoxicity and accumulation of pesticides in human biological matrices. Continuous and sublethal exposure to pesticides had been associated with oxidative stress, mutagenic and cell death. Exposure to pesticides exhibits increased level of DNA damage even if no detectable amounts of pesticides are seen in biological matrices by binding specific areas in the DNA. This interferes normal body systems and mutation in gene encoding specific activities which may lead to a wide range of cancer. Presence of pesticides compounds in human biological matrices had been evident from various studies. However, detection methods are complex and inconsistent, making it difficult to compare and generalize findings. This article provides insight into genotoxic effects, presence of pesticides and their metabolites in human biological matrices and the resultant health effects as measured by DNA damage, acetylcholinesterase (AChE) activity inhibition and other biomarkers of pesticides exposure.

摘要

由于农药在人体生物基质中的遗传毒性和积累，职业农药暴露会引起健康问题。持续和亚致死性接触农药与氧化应激、诱变和细胞死亡有关。即使通过结合 DNA 中的特定区域，在生物基质中看不到可检测量的农药，暴露于农药中也会增加 DNA 损伤水平。这会干扰正常的身体系统和编码特定活动的基因的突变，这可能导致广泛的癌症。各种研究表明，人类生物基质中存在农药化合物。然而，检测方法复杂且不一致，难以比较和概括结果。这篇文章提供了对基因毒性影响的见解，