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Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells.
Immunogenetics ( IF 2.9 ) Pub Date : 2019-11-18 , DOI: 10.1007/s00251-019-01141-w
Ludvig M Sollid 1 , Jason A Tye-Din 2 , Shuo-Wang Qiao 1 , Robert P Anderson 2 , Carmen Gianfrani 3 , Frits Koning 4
Affiliation  

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

中文翻译:

2020年更新:CD4 + T细胞识别的与腹腔疾病相关的面筋表位的命名和列表。

腹腔疾病是由对谷蛋白的异常肠道T细胞反应引起的。该疾病具有很强的人类白细胞抗原(HLA)关联,并且识别由疾病相关HLA-DQ同种异型呈现的面筋表位的CD4 + T细胞被认为是疾病的驱动因素。本文提供了当前已知的HLA-DQ限制的麸质T细胞表位的更新及其名称和序列。
更新日期:2020-04-21
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