Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Forty-six patients with MCI were divided into aMCI group (n = 23) and naMCI group (n = 23). The mean level of urinary AD7c-NTP in the aMCI group (32.75 ± 10.0 µg/mL) was significantly higher than that in the naMCI group (25.34 ± 9.0 µg/mL; P = .011). As far as we know, the present study is the first to show that individuals with aMCI have higher levels of urinary AD7c-NTP than those with naMCI, suggesting that urinary AD7c-NTP may be a potential biomarker to help identify patients with aMCI and naMCI.

中文翻译：

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遗忘性和非遗忘性轻度认知障碍患者尿液中阿尔茨海默病相关神经线蛋白 (AD7c-NTP) 水平的比较。


尿阿尔茨海默病相关神经丝蛋白 (AD7c-NTP) 是阿尔茨海默病 (AD) 或轻度认知障碍 (MCI) 的潜在生物标志物。目前尚不清楚遗忘性 MCI (aMCI) 和非遗忘性 MCI (naMCI) 患者的尿 AD7c-NTP 水平是否不同。本研究旨在探讨 aMCI 和 naMCI 患者尿 AD7c-NTP 水平的差异。 46 例 MCI 患者分为 aMCI 组（n = 23）和 naMCI 组（n = 23）。 aMCI 组尿 AD7c-NTP 平均水平 (32.75 ± 10.0 µg/mL) 显着高于 naMCI 组 (25.34 ± 9.0 µg/mL；P = .011)。据我们所知，本研究首次表明aMCI患者的尿液AD7c-NTP水平高于naMCI患者，这表明尿液AD7c-NTP可能是帮助识别aMCI和naMCI患者的潜在生物标志物。