Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Forty-six patients with MCI were divided into aMCI group (n = 23) and naMCI group (n = 23). The mean level of urinary AD7c-NTP in the aMCI group (32.75 ± 10.0 µg/mL) was significantly higher than that in the naMCI group (25.34 ± 9.0 µg/mL; P = .011). As far as we know, the present study is the first to show that individuals with aMCI have higher levels of urinary AD7c-NTP than those with naMCI, suggesting that urinary AD7c-NTP may be a potential biomarker to help identify patients with aMCI and naMCI.

中文翻译：

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遗忘性和非遗忘性轻度认知障碍患者之间尿液阿尔茨海默氏症相关的神经线蛋白（AD7c-NTP）水平的比较。

尿液阿尔茨海默氏症相关神经线蛋白（AD7c-NTP）是阿尔茨海默氏病（AD）或轻度认知障碍（MCI）的潜在生物标志物。尚不清楚遗忘性MCI（aMCI）和非遗忘性MCI（naMCI）患者的AD7c-NTP尿水平是否不同。本研究旨在探讨aMCI和naMCI患者之间AD7c-NTP尿液水平的差异。46例MCI患者分为aMCI组（n = 23）和naMCI组（n = 23）。aMCI组的尿AD7c-NTP平均水平（32.75±10.0 µg / mL）显着高于naMCI组（25.34±9.0 µg / mL； P = .011）。据我们所知，本研究是第一个表明患有aMCI的个体比具有naMCI的个体具有更高水平的尿液AD7c-NTP，