Animal models are in constant development to benefit scientific research. Rheumatoid arthritis (RA) is considered a very complex disease due to its complicated pathogenesis, and patients with rheumatic disease around the world are still unable to obtain effective, simple and curable treatment. In order to obtain a clear insight into the pathogenesis of RA, a rat model was established based on the concept of Bi syndrome in Traditional Chinese Medicine by simulating the conditions of RA as much as possible via the change in the physical conditions wind, damp, cold and heat (WDCH). For the first time, a new WDCH-induced RA model in female rats was successfully established and evaluated by body-weight change, paw swelling, blood cells analysis, spleen and thymus coefficients, autoantibodies and serum cytokine changes and histopathology. This model is characterised by its objectivity, no exogenous induction, short modelling time, extremely elevated expression level of autoantibodies and obvious histopathological change. The establishment of such a new model may provide more benefits in the research of the pathogenesis of RA.

中文翻译：

---

由风，湿，冷和热在雌性大鼠中诱发的新型关节炎模型。

为了促进科学研究，动物模型正在不断发展。由于类风湿关节炎（RA）的发病机理复杂，因此被认为是一种非常复杂的疾病，世界各地的风湿病患者仍无法获得有效，简单且可治愈的治疗方法。为了更清楚地了解RA的发病机理，根据中医Bi综合征的概念，通过改变风，湿，冷热（WDCH）。首次成功建立了新的WDCH诱导的雌性大鼠RA模型，并通过体重变化，爪肿胀，血细胞分析，脾脏和胸腺系数，自身抗体和血清细胞因子变化以及组织病理学对其进行了评估。该模型具有客观性，无外源诱导，建模时间短，自身抗体表达水平极高和明显的组织病理学改变等特点。建立这种新模型可能为RA的发病机理研究提供更多的益处。