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Ensembles in medial and lateral orbitofrontal cortex construct cognitive maps emphasizing different features of the behavioral landscape.
Behavioral Neuroscience ( IF 1.6 ) Pub Date : 2017-5-26 , DOI: 10.1037/bne0000195
Nina Lopatina 1 , Brian F Sadacca 1 , Michael A McDannald 2 , Clay V Styer 1 , Jacob F Peterson 1 , Joseph F Cheer 3 , Geoffrey Schoenbaum 1
Affiliation  

The orbitofrontal cortex (OFC) has long been implicated in the ability to use the current value of expected outcomes to guide behavior. More recently, this specific role has been conceptualized as a special case of a more general function that OFC plays in constructing a "cognitive map" of the behavioral task space by labeling the current task state and learning relationships among task states. Here, we have used single unit recording data from 2 prior studies to examine whether and how information relating different states within and across trials is represented in medial versus lateral OFC in rats. Using a hierarchical clustering analysis, we examined how neurons from each area represented information about differently valued trial types, defined by the cue-outcome pairings, versus how those same neurons represented information about similar epochs between these different trial types, such as the stimulus sample, delay, and reward consumption epochs. This analysis revealed that ensembles in the lateral OFC (lOFC) group states according to trial epoch, whereas those in the medial OFC (mOFC) organize the same states by trial type. These results suggest that the lOFC and mOFC construct cognitive maps that emphasize different features of the behavioral landscape, with lOFC tracking events based on local similarities, irrespective of their values and mOFC tracking more distal or higher order relationships relevant to value. (PsycINFO Database Record

中文翻译:

在内侧和外侧眶额皮质中的集合构成认知图,强调了行为景观的不同特征。

眼眶额皮质(OFC)长期以来牵涉使用预期结果的当前值来指导行为的能力。最近,这种特定角色已被概念化为OFC在通过标记当前任务状态和学习任务状态之间的关系来构造行为任务空间的“认知图”时所发挥的更一般功能的特例。在这里,我们使用了来自2项先前研究的单一单位记录数据,以检查在大鼠的内侧与外侧OFC中是否以及如何代表与试验内和试验间不同状态有关的信息。使用分层聚类分析,我们检查了来自每个区域的神经元如何表示有关不同价值的试验类型的信息,这些试验类型由提示结果配对定义,以及那些相同的神经元如何表示有关这些不同试验类型之间类似时期的信息,例如刺激样本,延迟和奖励消耗时期。该分析表明,根据试验时期,外侧OFC(10FC)组状态中的合奏,而根据试验类型,内侧OFC(mOFC)中的合奏则组织相同的状态。这些结果表明,lOFC和mOFC构造了强调行为格局不同特征的认知图,其中lOFC跟踪事件基于局部相似性,而不管其值如何,mOFC跟踪与价值相关的更远侧或更高阶的关系。(PsycINFO数据库记录 该分析表明,根据试验时期,外侧OFC(10FC)组状态中的合奏,而根据试验类型,内侧OFC(mOFC)中的合奏则组织相同的状态。这些结果表明,lOFC和mOFC构造了强调行为格局不同特征的认知图,其中lOFC跟踪事件基于局部相似性,而不管其值如何,mOFC跟踪与价值相关的更远侧或更高阶的关系。(PsycINFO数据库记录 该分析表明,根据试验时期,外侧OFC(10FC)组状态中的合奏,而根据试验类型,内侧OFC(mOFC)中的合奏则组织相同的状态。这些结果表明,lOFC和mOFC构造了强调行为格局不同特征的认知图,其中lOFC跟踪事件基于局部相似性,而不管其值如何,mOFC跟踪与价值相关的更远侧或更高阶的关系。(PsycINFO数据库记录 不管它们的值如何,并且mOFC都跟踪与价值有关的更远侧或更高阶的关系。(PsycINFO数据库记录 不管它们的值如何,并且mOFC都跟踪与价值有关的更远侧或更高阶的关系。(PsycINFO数据库记录
更新日期:2020-08-21
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