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Cue-induced food seeking after punishment is associated with increased Fos expression in the lateral hypothalamus and basolateral and medial amygdala.
Behavioral Neuroscience ( IF 1.6 ) Pub Date : 2017-02-20 , DOI: 10.1037/bne0000185
Erin J Campbell 1 , David J Barker 2 , Helen M Nasser 3 , Konstantin Kaganovsky 4 , Christopher V Dayas 1 , Nathan J Marchant 4
Affiliation  

In humans, relapse to unhealthy eating habits following dieting is a significant impediment to obesity treatment. Food-associated cues are one of the main triggers of relapse to unhealthy eating during self-imposed abstinence. Here we report a behavioral method examining cue-induced relapse to food seeking following punishment-induced suppression of food taking. We trained male rats to lever press for food pellets that were delivered after a 10-s conditional stimulus (CS) (appetitive). Following training, 25% of reinforced lever presses resulted in the presentation of a compound stimulus consisting of a novel CS (aversive) and the appetitive CS followed by a pellet and footshock. After punishment-imposed abstinence, we tested the rats in an extinction test where lever pressing resulted in the presentation of either the appetitive or aversive CS. We then compared activity of lateral hypothalamus (LH) and associated extrahypothalamic regions following this test. We also assessed Fos expression in LH orexin and GABA neurons. We found that cue-induced relapse of food seeking on test was higher in rats tested with the appetitive CS compared to the aversive CS. Relapse induced by the appetitive CS was associated with increased Fos expression in LH, caudal basolateral amygdala (BLA), and medial amygdala (MeA). This relapse was also associated with increased Fos expression in LH orexin and VGAT-expressing neurons. These data show that relapse to food seeking can be induced by food-associated cues after punishment-imposed abstinence, and this relapse is associated with increased activity in LH, caudal BLA, and MeA. (PsycINFO Database Record

中文翻译:

线索诱发的惩罚后寻求食物与下丘脑外侧,基底外侧和杏仁内侧的Fos表达增加有关。

在人类中,节食后恢复不健康的饮食习惯是肥胖症治疗的重要障碍。与食物有关的提示是自我禁欲期间不健康饮食复发的主要诱因之一。在这里,我们报告了一种行为方法,该方法检查了线索诱导的对食物寻求的惩罚,该惩罚是由于惩罚导致的对食物摄取的抑制。我们训练雄性大鼠杠杆压榨食物颗粒,这些颗粒是在10秒钟的条件刺激(CS)(可食性)后递送的。训练后,25%的增强杠杆压力导致了复合刺激的出现,该复合刺激由新颖的CS(渐进式)和具有吸引力的CS组成,随后是颗粒和脚底震荡。在施加惩罚性禁欲后,我们在灭绝试验中测试了老鼠,其中按下杠杆会导致出现食欲性或厌恶性CS。然后,我们在此测试后比较了下丘脑外侧(LH)和相关的下丘脑外区域的活动。我们还评估了LH食欲素和GABA神经元中的Fos表达。我们发现,与厌食性CS相比,用食性CS进行测试的大鼠因提示而寻求食物的复发率更高。食欲CS诱发的复发与LH,尾侧基底外侧杏仁核(BLA)和内侧杏仁核(MeA)中Fos表达增加有关。这种复发还与LH orexin和VGAT表达神经元中Fos表达的增加有关。这些数据表明,禁食后禁食可引起与食物相关的提示,从而导致觅食的复发,这种复发与LH,尾部BLA和MeA活性增加有关。(PsycINFO数据库记录 我们发现,与厌食性CS相比,用食性CS进行测试的大鼠因提示而寻求食物的复发率更高。食欲CS诱发的复发与LH,尾侧基底外侧杏仁核(BLA)和内侧杏仁核(MeA)中Fos表达增加有关。这种复发还与LH orexin和VGAT表达神经元中Fos表达的增加有关。这些数据表明,禁食后禁食可引起与食物相关的提示,从而导致觅食的复发,这种复发与LH,尾部BLA和MeA活性增加有关。(PsycINFO数据库记录 我们发现,与厌食性CS相比,用食性CS进行测试的大鼠因提示而寻求食物的复发率更高。食欲CS诱发的复发与LH,尾侧基底外侧杏仁核(BLA)和内侧杏仁核(MeA)中Fos表达增加有关。这种复发还与LH orexin和VGAT表达神经元中Fos表达的增加有关。这些数据表明,禁食后禁食可引起与食物相关的提示,从而导致觅食的复发,这种复发与LH,尾部BLA和MeA活性增加有关。(PsycINFO数据库记录 尾基底外侧杏仁核(BLA)和内侧杏仁核(MeA)。这种复发还与LH orexin和VGAT表达神经元中Fos表达的增加有关。这些数据表明,禁食后禁食可引起与食物相关的提示,从而导致觅食的复发,这种复发与LH,尾部BLA和MeA活性增加有关。(PsycINFO数据库记录 尾基底外侧杏仁核(BLA)和内侧杏仁核(MeA)。这种复发还与LH orexin和VGAT表达神经元中Fos表达的增加有关。这些数据表明,禁食后禁食可引起与食物相关的提示,从而导致觅食的复发,这种复发与LH,尾部BLA和MeA活性增加有关。(PsycINFO数据库记录
更新日期:2020-08-21
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