A 60-year-old woman presented to hospital with abdominal pain and massive weight loss. Imaging studies confirmed the presence of a tumor of the pancreas. Histologic analysis of the sampling performed by echoendoscopic ultrasound fine-needle aspiration found aspects evocative of adenosquamous carcinoma. This case report highlights the difficulties of clinical pathologic diagnosis for these occasionally composite tumors. The patient underwent palliative chemotherapy based on platinum and 5-fluorouracil, followed by second-line chemotherapy with FOLFIRI after progression. Adenosquamous carcinoma of the pancreas remains a rare tumor with very poor prognosis and limited therapeutic options.

一名60岁的妇女因腹痛和大量体重减轻到医院就诊。影像学研究证实了胰腺肿瘤的存在。通过超声内镜超声细针穿刺抽吸术进行的组织学分析发现了令人回味的腺鳞癌。该病例报告突出了这些偶发性复合肿瘤的临床病理诊断的困难。患者接受了以铂和5-氟尿嘧啶为基础的姑息化疗，然后在病情进展后进行了FOLFIRI的二线化疗。胰腺腺鳞癌仍然是一种罕见的肿瘤，预后非常差，治疗选择有限。