PURPOSE This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. METHODS This was a retrospective study where subjects aged 5-18 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. RESULTS A total of 71 normal eyes from 71 subjects were enrolled. For the macula, the mean VD of fovea, parafovea, and perifovea at superficial retina and deep retina were 20.1%, 50.2%, 49.4%, 36.1%, 53.9%, and 48.1%, respectively. The mean foveal avascular zone (FAZ) was 0.277 mm2. For optic disc, the mean VD of radial peripapillary capillary (RPC) and inside-disc areas were 51.8% and 51.7%, respectively. Significant differences were found between the superior-hemi and inferior-hemi VD of the superficial retinal parafovea, deep retinal perifovea, and perifovea. The fovea VD of the superficial and deep retina and FAZ areas were different between genders. The inside-disc VD was positively correlated with AL, while other VDs had no significant correlation with age and AL. CONCLUSIONS The parafovea VD of the superficial retina, parafovea, and perifovea of the deep retina had superior-hemi VD; boys had a higher fovea VD and smaller FAZ area than those of girls, the macular VD and peripapillary RPC density were steady for 5-18 year-olds. This study provided useful information for furthering the understanding of the development mode of vessel in children and the OCTA clinical applications in children.

中文翻译：

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通过光学相干断层扫描血管造影术对儿童正常眼睛中的黄斑和视盘的血管密度进行检测。

目的本研究旨在描述儿童正常眼中黄斑和视盘的血管密度（VD）的变化和特征。方法这项回顾性研究纳入了5-18岁正常眼睛的受试者。通过光学相干断层扫描血管造影术（OCTA）扫描黄斑和视盘。分析了年龄，性别和轴向长度（AL）对VD的影响。结果共纳入了来自71位受试者的71只正常眼。对于黄斑，浅表视网膜和深视网膜的中央凹，副中央凹和中央凹的平均VD分别为20.1％，50.2％，49.4％，36.1％，53.9％和48.1％。平均中央凹无血管区域（FAZ）为0.277 mm2。对于视盘，radial状乳头周围毛细血管（RPC）和椎间盘内区域的平均VD分别为51.8％和51.7％。发现浅视网膜视网膜中央凹，深视网膜周围凹和周围凹的上半部和下半部VD之间存在显着差异。浅表和深视网膜的中央凹VD和FAZ区域在性别上是不同的。盘内VD与AL呈正相关，而其他VD与年龄和AL无显着相关。结论浅表视网膜的副凹VD，深视网膜的副凹和副凹具有上半部VD。男孩比女孩有更高的中央凹VD和更小的FAZ区域，黄斑区VD和乳头周围RPC密度在5-18岁之间稳定。这项研究为进一步了解儿童血管发育模式和儿童OCTA临床应用提供了有用的信息。