d-Cycloserine (DCS) is a partial agonist of the glutamatergic N-methyl-d-aspartate (NMDA) receptor-associated glycine site, and it prevents the amnesic effects of the muscarinic receptor antagonist scopolamine in various memory tests in rodents. In the present study, we tested the hypothesis that DCS has anti-amnesic effects in scopolamine-induced deficits using spontaneous object recognition and place recognition tests. In both tests, scopolamine (0.5 mg/kg, i.p.) was systemically administered 60 min prior to testing, while DCS (7.5, 15, 30 mg/kg, i.p.) was administered 30 min before testing, which consisted of a sample phase (5 min), a delay interval (15 min) and a test phase (2 min). DCS treatment reversed scopolamine-induced deficits in discriminatory behavior during the test phase. However, DCS did not affect decreased object exploration itself or increased thigmotaxis in the open-field arena induced by scopolamine. These results support our hypothesis and suggest differential contributions of glutamatergic-cholinergic system interactions to recognition memory and non-mnemonic exploratory behaviors.

d-环丝氨酸（DCS）是谷氨酸能N-甲基-d的部分激动剂-天冬氨酸（NMDA）受体相关的甘氨酸位点，在鼠类的各种记忆测试中，它可防止毒蕈碱受体拮抗剂东pol碱的记忆删除作用。在本研究中，我们使用自发物体识别和位置识别测试测试了DCS在东pol碱引起的赤字中具有抗记忆删除的假设。在这两项测试中，东pol碱（0.5 mg / kg，ip）在测试前60分钟进行全身性给药，而DCS（7.5，15，30 mg / kg，ip）在测试前30 min进行全身给药，其中包括样品阶段（ 5分钟），延迟间隔（15分钟）和测试阶段（2分钟）。在试验阶段，DCS治疗逆转了东pol碱引起的歧视性行为缺陷。然而，DCS不会影响东pol碱所致开放视野中物体探测本身的减少或触轴的增加。这些结果支持我们的假设，并暗示了谷氨酸能与胆碱能系统相互作用对识别记忆和非记忆性探索行为的不同贡献。