Multidrug resistant bacterial pathogens as causative agents of infectious disease are a primary public health concern. Clinical efficacy of antimicrobial chemotherapy toward bacterial infection has been compromised in cases where causative agents are resistant to multiple structurally distinct antimicrobial agents. Modification of extant antimicrobial agents that exploit conventional bacterial targets have been developed since the advent of the antimicrobial era. This approach, while successful in certain cases, nonetheless suffers overall from the costs of development and rapid emergence of bacterial variants with confounding resistances to modified agents. Thus, additional strategies toward discovery of new molecular targets have been developed based on bioinformatics analyses and comparative genomics. These and other strategies meant to identify new molecular targets represent promising avenues for reducing emergence of bacterial infections. This short review considers these strategies for discovery of new molecular targets within bacterial pathogens.

中文翻译：

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发现抗感染药物新分子靶标的策略。

作为传染病的病原体的耐多药细菌病原体是主要的公共卫生问题。在病原菌对多种结构不同的抗微生物药产生耐药性的情况下，抗微生物化学疗法对细菌感染的临床疗效已受到损害。自抗微生物时代来临以来，已经开发了利用常规细菌靶的现存抗微生物剂的改性方法。这种方法虽然在某些情况下是成功的，但总的来说遭受了细菌变体的发展和快速出现的代价，并且对修饰剂的抗性混杂。因此，基于生物信息学分析和比较基因组学，已经开发了发现新分子靶标的其他策略。这些和其他旨在确定新的分子靶标的策略代表了减少细菌感染出现的有前途的途径。这篇简短的评论考虑了这些在细菌病原体中发现新分子靶标的策略。