In recent years, the number of pathogenic microorganisms resistant to antibiotics has increased alarmingly. For the next 10-20 years, health organizations forecast high human mortality caused by these microorganisms. Therefore, the search for new anti-infectives is quite necessary and urgent. Traditionally, antibiotic-producing microorganisms have been isolated from common soil samples. However, this source seems to be exhausted considering the very few examples of antibiotic-producing microorganisms reported recently. In this review, non-conventional sources of anti-infective producing microorganisms are presented as a possible way to look for new and more effective compounds. These sources included arid soils, caves, areas with high temperatures (hot springs), high salinity or oceans and seas. Finally, other non-conventional sources of antibiotics reviewed are animal and invertebrate venoms, among others.

中文翻译：

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具有抗感染活性的分子的最新发现：非常规来源的筛选。

近年来，对抗生素具有抗性的病原微生物的数量惊人地增加。在接下来的10-20年中，卫生组织预测，由这些微生物引起的高人类死亡率。因此，寻找新的抗感染药是非常必要和紧迫的。传统上，已从普通土壤样品中分离出产生抗生素的微生物。但是，考虑到最近报道的抗生素产生微生物的例子很少，这种来源似乎已经用尽。在这篇综述中，提出了抗感染产生微生物的非常规来源，作为寻找新的，更有效的化合物的可能途径。这些来源包括干旱的土壤，洞穴，高温（温泉），高盐度或海洋的区域。最后，