当前位置: X-MOL 学术Synapse › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
In vivo voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine in the infralimbic cortex: Effect of acute ethanol.
SYNAPSE ( IF 1.6 ) Pub Date : 2018-11-22 , DOI: 10.1002/syn.22080
Alex L Deal 1 , Maria A Mikhailova 2 , Valentina P Grinevich 1 , Jeff L Weiner 3 , Raul R Gainetdinov 2 , Evgeny A Budygin 1, 2
Affiliation  

Using fast-scan cyclic voltammetry paired with pharmacology, the authors show that infralimbic catecholamine release following locus coeruleus stimulation is noradrenergic, but not dopaminergic, and not affected by acute ethanol. With previous work, these data suggest differential effects of ethanol on prefrontal norepinephrine and dopamine, a region important in addiction-related pathways.

中文翻译:

体内伏安法证据表明,蓝藻激活的部位主要在下肢皮质中释放去甲肾上腺素:急性乙醇的作用。

使用快速扫描循环伏安法和药理学相结合,作者表明,在蓝斑蓝斑刺激后,下唇儿茶酚胺释放是去甲肾上腺素能的,而不是多巴胺能的,并且不受急性乙醇的影响。在以前的工作中,这些数据表明乙醇对前额叶去甲肾上腺素和多巴胺(与成瘾有关的通路很重要的区域)的差异作用。
更新日期:2019-11-01
down
wechat
bug