OBJECTIVE IL23R plays an important role in the pathogenesis of inflammatory bowel disease (IBD). The IL23R rs11209026 and rs10889677 polymorphisms have been shown to be associated with the development of Crohn's disease (CD) and ulcerative colitis (UC). But the results were inconsistent and inconclusive. So, we aim to investigate the genetic association between rs11209026 and rs10889677 polymorphisms and UC and CD risk by a meta-analysis. METHODS Literature search was conducted through PubMed, CNKI, and web of science databases. Pooled OR and 95% CI was used to assess the association between the allelic, dominant and recessive models of IL23R rs11209026 and rs10889677 polymorphisms and UC and CD risk. RESULTS 41 publications with 13,803 patients with CD and 17,446 controls, as well as 5876 patients with UC and 10,053 controls were included in the present study. All the genetic models of rs11209026 polymorphism significantly decrease CD and UC risk (except for the recessive model in UC) (p < 0.05). A subgroup analysis based on ethnicity showed that the allelic (p < 0.00001, OR = 0.65) and dominant models (p < 0.00001, OR = 0.61) of rs11209026 polymorphism were significantly associated with UC risk in Caucasians, but not in Asians (p > 0.05). In addition, the allelic (CD: p < 0.00001, OR = 1.34; UC: p < 0.00001, OR = 1.22) and dominant models (CD: p = 0.002, OR = 1.39; UC: p = 0.01, OR = 1.29), but not the recessive model of rs10889677 polymorphism significantly increase the risk of CD and UC (p > 0.05). A subgroup analysis showed that the genetic models of rs10889677 polymorphism were associated with CD risk in Caucasians (p < 0.05), but not in Asians (p > 0.05). The dominant model of rs10889677 polymorphism was associated with UC risk in Asians (p = 0.04, OR = 1.54), but not in Caucasians (p > 0.05). CONCLUSIONS Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.

中文翻译：

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IL23R rs11209026 和 rs10889677 多态性与克罗恩病和溃疡性结肠炎风险之间的遗传关联：来自 41 项研究的证据。

目的 IL23R 在炎症性肠病 (IBD) 的发病机制中起重要作用。IL23R rs11209026 和 rs10889677 多态性已被证明与克罗恩病 (CD) 和溃疡性结肠炎 (UC) 的发展有关。但结果不一致且不确定。因此，我们旨在通过荟萃分析研究 rs11209026 和 rs10889677 多态性与 UC 和 CD 风险之间的遗传关联。方法通过PubMed、CNKI和web of science数据库进行文献检索。合并 OR 和 95% CI 用于评估 IL23R rs11209026 和 rs10889677 多态性的等位基因、显性和隐性模型与 UC 和 CD 风险之间的关联。结果 41 篇出版物中有 13,803 名 CD 患者和 17,446 名对照，以及 5876 名 UC 患者和 10 名，本研究包括 053 名对照。所有 rs11209026 多态性遗传模型均显着降低 CD 和 UC 风险（UC 中的隐性模型除外）（p < 0.05）。基于种族的亚组分析表明，rs11209026 多态性的等位基因 (p < 0.00001, OR = 0.65) 和显性模型 (p < 0.00001, OR = 0.61) 与白种人的 UC 风险显着相关，但在亚洲人中则没有 (p > 0.05)。此外，等位基因（CD：p < 0.00001，OR = 1.34；UC：p < 0.00001，OR = 1.22）和显性模型（CD：p = 0.002，OR = 1.39；UC：p = 0.01，OR = 1.29） , 但不是 rs10889677 多态性的隐性模型显着增加了 CD 和 UC 的风险 (p > 0.05)。亚组分析表明，rs10889677 多态性的遗传模型与白种人的 CD 风险相关（p < 0.05），但在亚洲人中没有（p > 0.05）。rs10889677 多态性的主要模型与亚洲人的 UC 风险相关（p = 0.04，OR = 1.54），但与白种人无关（p > 0.05）。结论 我们的荟萃分析表明，rs11209026 多态性可能是 IBD 发生的保护因素，而 rs10889677 多态性可能是 IBD 的危险因素。