Abstract In this paper, two medusa-like ACyDs, modified at the primary rim bearing four (ACyD4) and eight carbons (ACyD8) acyl chain length, and one bouquet-like CyD, modified at primary side with thiohexyl and at secondary one with oligoethylene moiety (SC6OH), were investigated for their ability to assemble in nanostructures or to form hybrid dipalmitoylphosphatidylcholine (DPPC)/ACyDs systems. The lipophilicity of these molecules and the different preparation methods used in this study (thin layer evaporation and nanoprecipitation method) significantly affect the aggregation behaviour in aqueous medium. Except for the shortest medusa-like ACyD4, the other ACyDs formed stable nanoaggregates for at least 45 days. The effect of ACyDs on the thermotropic behaviour of DPPC liposomes was also studied by differential scanning calorimetry analysis, thus elucidating their interaction with liposomes to afford hybrid liposome/ACyDs systems. The medusa-like ACyD4 cannot be used to realize nanosystems because it quickly aggregates or it induces a complete destabilization of the liposomes. At the highest concentration investigated (0.01 molar fraction), both ACyD8 and SC6OH interacted with DPPC liposomes, forming ACyD/DPPC or SC6OH/DPPC hybrid vesicular carriers.

中文翻译：

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具有药物载体潜力的两亲性环糊精/脂质体纳米组件的物理化学研究

摘要 在本文中，两个类似美杜莎的 ACyD，在初级边缘修饰，具有四个（ACyD4）和八个碳（ACyD8）酰基链长度，以及一个花束状 CyD，在初级侧用硫己基修饰，在次级侧用低聚乙烯修饰。部分 (SC6OH)，研究了它们在纳米结构中组装或形成混合二棕榈酰磷脂酰胆碱 (DPPC)/ACyDs 系统的能力。这些分子的亲脂性和本研究中使用的不同制备方法（薄层蒸发和纳米沉淀法）显着影响了水性介质中的聚集行为。除了最短的类似美杜莎的 ACyD4，其他 ACyD 形成稳定的纳米聚集体至少 45 天。还通过差示扫描量热分析研究了 ACyDs 对 DPPC 脂质体热致行为的影响，因此阐明了它们与脂质体的相互作用以提供混合脂质体/ACyDs 系统。类似美杜莎的 ACyD4 不能用于实现纳米系统，因为它会快速聚集或导致脂质体完全不稳定。在研究的最高浓度（0.01 摩尔分数）下，ACyD8 和 SC6OH 都与 DPPC 脂质体相互作用，形成 ACyD/DPPC 或 SC6OH/DPPC 混合囊泡载体。