Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully restoring its size, shape and tissue patterning. Studies over the past decades have identified mechanisms underlying the formation, spatial organization, and regenerative growth of the blastema, a pool of proliferative progenitor cells. The patterning of newly forming tissue is tightly regulated to ensure proper rebuilding of anatomy. Precise niche regulation of retinoic acid and sonic hedgehog signaling ensures adherence to ray—interray boundaries. The molecular underpinnings of systems underlying re‐establishment of pre‐amputation size and shape (positional information) are also slowly starting to emerge. Osteoblasts play an important role as a cellular source of regenerating skeletal elements, and in zebrafish both osteoblast dedifferentiation as well as de novo osteoblast formation occurs. Both dedifferentiation and proliferation are tightly controlled, which makes it interesting to compare it to tumorigenesis, and to identify potential players involved in these processes.

中文翻译：

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在了解斑马鱼鳍再生方面的最新进展。

斑马鱼具有出色的能力，可以完全重建丢失的肢体，忠实地恢复其大小，形状和组织图案。过去数十年的研究已经确定了胚泡，增殖祖细胞池的形成，空间组织和再生生长的潜在机制。严格调节新形成的组织的图案，以确保正确重建解剖结构。视黄酸和声音刺猬信号的精确生态位调节可确保遵守射线间的边界。重新建立预截面积和形状（位置信息）基础的系统的分子基础也正在慢慢出现。成骨细胞作为再生骨骼元素的细胞来源发挥着重要作用，在斑马鱼中，成骨细胞的去分化以及从头发生成骨细胞形成。去分化和增殖都受到严格控制，这使得将其与肿瘤发生进行比较，并确定参与这些过程的潜在参与者非常有趣。